List direct access : telemetry
First screening First screening
Telemetric Long-term follow-up
recognition Learning – Memory
sensitization Drug Abuse - Pharmacodependence
Chronic Depression
box Anxiety - Stress -OCD
Catalepsy Psychosis
Rotarod Motor
reaction Attention – Impulsivity - Attention Deficit/Hyperactivity Disorder (ADHD)
Sickness Pain – Inflammation
Alzheimer Neurodegenerative diseases

The following tests are validated at the Key-Obs laboratory.
They are regularly carried out, in controlled experimental conditions.
They can be conducted for either pharmacology testing or behavioral phenotyping.


ActimeterFirst screening First screening
Pharmacology: Irwin modified test (mouse)
Behavioral phenotyping : Primary screen (mouse)
Acute toxicity : LD50 (mouse, rat)
Spontaneous activity in an open field (mouse, rat)


Long-term follow-up Long-term follow-up
Telemetric measurement of activity, temperature, heart rate (mouse)
Activity in an open-field (mouse, rat)


Learning – Memory (working/reference/episodic memory – spatial/non spatial – habituation) Learning – Memory (working/reference/episodic memory – spatial/non spatial – habituation)
Object recognition (mouse, rat) Click here to see the test
Passive avoidance (mouse)
Spontaneous alternation in a Y-maze (mouse) Click here to see the test
Place recognition in a Y-maze (rat)
MorrisHabituation in an open-field (mouse, rat)
One-trial learning in an elevated plus maze (mouse)
Morris water maze – Acquisition – Reference memory – Working memory (mouse, rat)
Radial maze – Acquisition – Reference memory – Working memory (mouse, rat)
Radial maze –Working/episodic memory : Delayed-Non-Matching-To-Sample (rat)


Drug Abuse - Pharmacodependence Drug Abuse - Pharmacodependence
drug preparationBehavioral sensitization (mouse, rat)
Place preference (mouse, rat)
Opiate withdrawal (mouse, rat) Click here to see the test
Benzodiazepine withdrawal (mouse) Click here to see the test
Alcohol withdrawal (mouse, rat)
Alcohol consumption (mouse)
Opiate self administration (mouse) Click here to see the test

Depression Depression
Forced swimming test (mouse, rat) - Click here to see the test
Tail suspension test (mouse)
Chronic mild stress (mouse) - Click here to see the test

Anxiety Anxiety - Stress -OCD
Elevated plus maze (mouse, rat) Click here to see the test
Light/dark box (mouse) Click here to see the test
Four plates test (mouse)
Marble burying test (mouse) Click here to see the test
Stress induced hyperthermia (mouse) Click here to see the test
Anxiety swim stress (rat) Click here to see the test

Psychosis Psychosis
Catalepsy
Antagonism of effects (hypothermia, stereotypies, hyperactivity) of apomorphine (mouse) Click here to see the test
Antagonism of hyperactivity-induced by MK-801 (mouse)Test attention
Antagonism of PCP-induced stereotypies (mouse)

Motor Motor
Rotarod (mouse, rat)
Grip strength (mouse)
Locomotor activity (mouse, rat)

Attention – Impulsivity Attention – Impulsivity
Five-choice reaction time (mouse)


Impulsive behaviours: ADHD, suicide, OCD Attention Deficit/Hyperactivity Disorder (ADHD)
T-maze-ADHD (rat) - Click here to see the test


Pain – Inflammation Pain – Inflammation
Sickness behavior induced by LPS (rat)
Pain, see partners

Neurodegenerative diseases (Alzheimer – Parkinson – Huntington chorea) and aging Neurodegenerative diseases (Alzheimer – Parkinson – Huntington chorea) and aging
Aging : memory deficits induced by age (mouse, rat)
Alzheimer disease : memory deficits induced by scopolamine (mouse, rat)
Alzheimer disease : memory deficits induced by β-amyloid protein (rat)
Parkinson disease : motor deficits and dopamine depletion induced by MPTP (mouse)
Huntington chorea : motor deficits induced by 3-NP (rat) - Click here to see the test
 
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