Preclinical Contract Research Organization
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Central Nervous System research
PSYCHIATRIC DISEASES
ADHD
(Attention Deficit/Hyperactivity Disorder) - Impulsive Behavior
- Delayed discounting task in T-maze
Anxiety - Stress
- Elevated plus maze (EPM)
- Four-plate
- Stress-induced anxiety in EPM
- Stress-induced hyperthermia
Anxiety - Obsessive-compulsive disorder (OCD)
- Marble burying test
Bipolar disorder
- Amphetamine/Chlordiazepoxide hyperactivity
Depression
- Forced swimming test
- Tail suspension test
Pharmacodependence Addiction
- Behavioral sensitization
- Alcohol intake
- Conditioned place preference
- Withdrawal (opiate, benzodiazepines)
Schizophrenia
- Apomorphine test (hypothermia, stereotypy, climbing)
- Amphetamine hyperactivity
- MK-801, PCP hyperactivity
- MK-801 amnesia in Y-maze
- Social deficit induced by MK-801
- Catalepsy: bar test
FUNCTIONS
Activity, motor function
- Spontaneous activity in open-field
- Rotarod
- Grip strength
- Bar test
- nclined plane test
- Negative geotaxis
Learning and Memory
- Spontaneous alternation in Y-maze
- Novel Object Recognition
- Social recognition
- Passive avoidance
- Habituation in open-field
- Morris Water Maze
NEURODEGENERATIVE AND NEURODEVELOPMENTAL DISEASES
Alzheimer Disease
- Memory deficit induced by scopolamine
- Memory deficit in APP-Tg2576 mice
Parkinson Disease
- MPTP: Motor deficit DA depletion
- 6-OHDA unilateral lesion
Autism
- Social deficit induced by prenatal exposure to Valproic Acid (VPA)
Amyotrophic Lateral Sclerosis
- SOD transgenic rats and mice
- NEW!!! Amyotrophic Lateral Sclerosis
IN DEVELOPMENT
- Two-choice visual discrimination task in operant chamber
- Depressive-like state induced by LPS