Neuroinflammation
Inflammation in preclinical models of neurodegenerative disorders
A joint expertise
Key-Obs and Artimmune combine complementary know-how and technical skills to study inflammation in brain diseases.
What we measure
Technical capabilities
A full analytical toolbox to characterize neuro-inflammation at the tissue, protein and molecular level on brain and spinal-cord samples from our in vivo models.
SIMOA method (Quanterix)
Detection of neurological biomarkers at ultra-low levels in blood and several others associated with brain injury and diseases. Ex :
- Neurofilament Light (NfL),
- Tau proteins
- GFAP
- Amyloid proteins
- Cytokines
A very useful method for longitudinal studies of the long-term effects of your compound avoiding invasive measures.
Do not hesitate to ask for all the biomarkers we can measure in an unique sample!
Histology
Tissus
- Brain
- Spinal cord
Immunohistochemistry
Labelling of neuronal and glial markers on tissue sections.
Markers
- Iba-1
- GFAP
- TH
Biochemistry — WB & rtPCR
Protein and gene-expression quantification.
Targets
- caspase-3
- Bax
- Bcl-2
- GFAP
- TH
Immunological analysis
Cytokine and inflammatory-mediator profiling.
Cytokines
- IL-1β
- IL-6
- IL-10
- TGF-β
- TNF-α
- NfL
Applications
In specific disease models
Our neuro-inflammation package is applied across established models of neurodegenerative and psychiatric conditions.
Neurodegenerative diseases
- Amyotrophic Lateral Sclerosis
- Alzheimer's disease
- Parkinson disease
- Huntington disease
psychiatric disorders
- Autism
- Depression
- Stress / Anxiety
- ADHD
A project? Let's talk.
Tell us about your target and we’ll design the right combination of in vivo model and inflammation read-outs together with Artimmune.