tests & models
CNS diseases
PSYCHIATRIC DISEASES
ADHD
Attention-deficit / hyperactivity & impulsive behaviour.
- Delayed discounting task in T-maze
Anxiety & stress
Screening anxiolytic activity and stress responses.
- Elevated plus maze (EPM)
- Four-plate test
- Stress-induced anxiety in EPM
- Stress-induced hyperthermia
OCD
Anxiety – Obsessive-compulsive disorder
- Marble burying test
Bipolar disorder
Manic-like hyperactivity models.
- Amphetamine / chlordiazepoxide hyperactivity
Depression
Antidepressant screening paradigms.
- Forced swimming test
- Tail suspension test
Pharmacodependence Addiction
Reward, sensitisation and withdrawal.
- Behavioral sensitization
- Alcohol intake
- Conditioned place preference
- Withdrawal (opiate, benzodiazepines)
Schizophrenia
Positive, negative & cognitive symptom models.
- Apomorphine test (hypothermia, stereotypy, climbing)
- Amphetamine hyperactivity
- MK-801 / PCP hyperactivity
- Social deficit induced by MK-801
- Catalepsy: bar test
Functions
Activity & motor function
Locomotion, coordination and muscle strength.
- Spontaneous activity in open-field
- Rotarod
- Grip strength
- Bar test
- Inclined plane test
- Negative geotaxis
Learning & memory
Cognition and memory assessment.
- Spontaneous alternation in Y-maze
- Novel object recognition
- Social recognition
- Passive avoidance
- Habituation in open-field
- Morris water maze
Neurodegenerative & neurodevelopmental diseases
Alzheimer's disease
Cognitive-deficit and transgenic models.
- Memory deficit induced by scopolamine
- Memory deficit in APP-Tg2576 mice
Parkinson's disease
Dopaminergic lesion and motor deficit.
- MPTP: motor deficit, DA depletion
- 6-OHDA unilateral lesion
Autism
Neurodevelopmental social-deficit model.
- Social deficit induced by prenatal valproic acid (VPA)
Amyotrophic lateral sclerosis
Motor-neuron degeneration models.
- SOD transgenic rats and mice
- Amyotrophic Lateral Sclerosis
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